The heart: The cellular therapy

The heart derives from the mesoderma, but what is fundamental, to understand the finality of the use staminale, is the formality of the embryological formation of the organ, it happens for proliferation of the miocardiocitis and not for ipertrofia.To isto-cytological level, the 70% of the mass miocardica is constituted by miociti, other present cells to constitute the muscular smooth and cells endoteliali are her/it; made this premise you/he/she must be explained to the readers of the blog that a miocardiocita withdrawn by the cardiac fabric and positioned on plate it will never reenter in cellular cycle but a cell staminale (endowed with self-renewal,multipotenza and ability to give clones) him... therefore it was alone necessary to find, if you introduce, these cells to level of the heart and this has been done, he doesn't know, however, of their origin (it seems that they derive from the circle or from a portion of residual fetal miocardio). Most frequent cardiac pathology is the illness coronarica that is usually provoked by phenomenons aterosclerotici,ma it is necessary to underline that the suddetis phenomenons reenter in the category "events mended you", I am, instead, the "complicanze" of the aterosclerosi to provoke the irreparable damage.

Subsequently to a sindr. cor. acute the heart lives one period of chronic scompenso that brings to the death 3 on 5 stricken pzes in the 5 year-old turn (rate of incidence more elevated than in the neoplasias), aforesaid scompenso is characterized by cicatrizzazione fibrotica and therefore not able to contract himself/herself/themselves of the stricken zone, widening of the cardiac room and finally, but not for order of importance the ipertrofizzazione of the survived miocardiocitis. The medicines can exclusively slow down, when anchors is us in acute phase the progression toward the scompenso but a cell installed staminale and able to create clones can replace the miocitis in necrosis and can assume the characteristic contractility, fundamental to avoid the death of the individual!For close examinations on the theme there are publications on: 'The New England Journal of Medicines' and on 'Cell'...I attend around your signalings on articles and publications for the web riguardanti the matter, thanks!